Specific Allele Myo5a^d-19DThWb

Specific Allele Myo5a^d-23R
ORNL Allele Name	Myo5a^d-19DThWb or Myo5a^d-19DThWb
Belongs to Generic Allele group	Myo5a^d-pl (dilute; prenatally lethal)
Locus Name	Myo5a= d (myosin Va = dilute)
Alternate Allele name	Myo5a^d-23R, d^19DThWb, d^Aa3
Mutation Type	Multi-Locus Deletion
Chromosome	9
Molecular/physical characteristics	Deletes probe p94.1 but not p0.3.
Nearest Non-deleted Sites	l9Rl7) --- deletion --- (p0.3
Farthest Deleted Sites	(p94.1 - Myo5a)
Origin	ORNL, induced
Mutagen	X-ray
Fractions	6 x 300 cGy (7-day intervals)
Dose Rate	~ 90 cGy/min
Male Parent (Mutagenized)	(101/Rl x C3H/Rl)F₁
Female Parent	multiple-recessive tester (T-stock)
Germ-Cell Type Exposed	stem-cell spermatogonia
Oak Ridge Publications regarding Myo5a^d-19DThWb
Russell, L. B., Mutation Res. 11:107-123, 1971.
Kingsley, D. M., et al., EMBO J. 9: 395-399, 1990.
Rinchik, E. M., et al., Genetics 112:321-342, 1986.
ORNL Stock Name Formal Name	19DThWb STOCK Myo5a^d-23R +/Myo5a^d Bmp5^se or STOCK Myo5a^d-23R +/ + Bmp5^se
ORNL Availability	Frozen Sperm, Frozen Ovaries
ORNL Strain Type	Non-Inbred

Genotype	Phenotypes involving Myo5a^d-19DThWb
Genotype	Code	Code Definition	Additional Comments
Myo5a^d-19DThWb/+	0	Appears wild-type
Myo5a^d-19DThWb/Myo5a^d-19DThWb	18A	Prenatal lethality
Myo5a^d-19DThWb/Myo5a^d	1A	Hair pigment reduced or altered all over	Pigmentation like Myo5a^d/Myo5a^d.
Myo5a^d-19DThWb hemizygous	18A	Prenatal lethality