| Specific Allele Myo5ad-25R | |
| ORNL Allele Name | Myo5ad-19R145H or Myo5a^d-19R145H |
| Belongs to Generic Allele group | Myo5ad-pl (dilute; prenatally lethal) |
| Locus Name | Myo5a= d (myosin Va = dilute) |
| Alternate Allele name | Myo5ad-25R, d19R145H, dAa2 |
| Mutation Type | Multi-Locus Deletion |
| Chromosome | 9 |
| Molecular/physical characteristics | Breakpoint cloned. |
| Nearest Non-deleted Sites | l9Rl7) --- deletion --- (l9Rl8 |
| Farthest Deleted Sites | (? - p99.1-p0.3) |
| Origin | ORNL, induced |
| Mutagen | neutrons |
| Fractions | 1 x 145 cGy |
| Dose Rate | 88 cGy/min |
| Male Parent (Mutagenized) | (101/Rl x C3H/Rl)F1 |
| Female Parent | multiple-recessive tester (T-stock) |
| Germ-Cell Type Exposed | stem-cell spermatogonia |
Oak Ridge Publications regarding Myo5ad-19R145H |
|
| Russell, L. B., Mutation Res. 11:107-123, 1971. | |
| Kingsley, D. M., et al., EMBO. J. 9: 395-399, 1990. | |
| Rinchik, E. M., et al., Genetics 112:321-342, 1986. | |
| ORNL Stock Name Formal Name |
19R145H STOCK Myo5ad-25R +/Myo5ad Bmp5se or STOCK Myo5ad-25R +/ + Bmp5se |
| ORNL Availability | Frozen Sperm, Frozen Ovaries, Frozen Tissues |
| ORNL Strain Type | Non-Inbred |
| Genotype | Phenotypes involving Myo5ad-19R145H | ||
|---|---|---|---|
| Code | Code Definition | Additional Comments | |
| Myo5ad-19R145H/+ | 0 | Appears wild-type | |
| Myo5ad-19R145H/Myo5ad-19R145H | 18A | Prenatal lethality | |
| Myo5ad-19R145H/Myo5ad | 1A | Hair pigment reduced or altered all over | Pigmentation like Myo5ad/Myo5a |
| Myo5ad-19R145H hemizygous | 18A | Prenatal lethality | |
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