Specific Allele Myo5a^d-21R75M

Specific Allele Myo5a^d-36R
ORNL Allele Name	Myo5a^d-21R75M or Myo5a^d-21R75M
Belongs to Generic Allele group	Myo5a^d-pl (dilute; prenatally lethal)
Locus Name	Myo5a= d (myosin Va = dilute)
Alternate Allele name	Myo5a^d-36R, d^21R75M, d^Af2
Mutation Type	Multi-Locus Deletion
Chromosome	9
Molecular/physical characteristics	Deletes probe p94.1, but not p0.3
Nearest Non-deleted Sites	Rab27a) --- deletion --- (p0.3
Farthest Deleted Sites	(l9Rl2 - Myo5a)
Origin	ORNL, induced
Mutagen	neutrons
Fractions	1 x 75 cGy
Dose Rate	0.8 cGy/min
Male Parent (Mutagenized)	(101/Rl x C3H/Rl)F₁
Female Parent	multiple-recessive tester (T-stock)
Germ-Cell Type Exposed	stem-cell spermatogonia
Oak Ridge Publications regarding Myo5a^d-21R75M
Russell, L. B., Mutation Res. 11:107-123, 1971.
Kingsley, D. M., et al., EMBO. J. 9: 395-399, 1990.
Rinchik, E. M., et al., Genetics 112:321-342, 1986.
ORNL Stock Name Formal Name	21R75M STOCK Myo5a^d-36R +/Myo5a^d Bmp5^se or STOCK Myo5a^d-36R +/ + Bmp5^se
ORNL Availability	Frozen Embryos, Frozen Sperm, Frozen Tissues
ORNL Strain Type	Non-Inbred

Genotype	Phenotypes involving Myo5a^d-21R75M
Genotype	Code	Code Definition	Additional Comments
Myo5a^d-21R75M/+	0	Appears wild-type
Myo5a^d-21R75M/Myo5a^d-21R75M	18A	Prenatal lethality
Myo5a^d-21R75M/Myo5a^d	1A	Hair pigment reduced or altered all over	Pigmentation like Myo5a^d/Myo5a^d.
Myo5a^d-21R75M hemizygous	18A	Prenatal lethality