Genetic variation in the health outcome of exposure
to low doses of ionizing radiation

Project Leader: B. H. Voy

The detrimental effects of high doses of radiation are well-known, but the physiological consequences of lower doses are poorly defined. Standard and recombinant inbred strains of mice are used to dissect robust responses to low dose exposures from those that depend on genetic background. Transcriptome profiling is combined with functional responses and pathway mining tools to identify the molecular mechanisms that underlie low dose radiation effects.

More Low Dose Project Information

• Extracting Gene Networks for Low-Dose Radiation Using Graph Theoretical Algorithms (PLoS Computational Biology, Volume 2, Issue 7, July 2006)
• Low Dose Radiation Research - Currently Funded Projects
• Genetic Background Significantly Alters the Response to Low Dose Ionizing Radiation In Vivo
• Genetic Variation in Tissue Responses to Low-dose Radiation